The period after 1839 is known as the Tanzimat (restructuring) era. The significance of this era is that the initiative for modernization came from government officials with the compliance of the sultan. Economically, the Tanzimat, which marked the beginning of one of the most important turning points of Turkish-Ottoman history, has been intensively discussed after its proclamation in 1839. The second half of the Ottoman nineteenth century observed clear “Eurocentric Business Enterprises” in Ottoman economic and commercial life, consisting mostly of railway projects, as European centered commercial relations within international markets expanded. Reforms and changes in the commercial law system after the Tanzimat saw an increase in market efficiency of Levantine merchants in Ottoman domestic and foreign trade. Among these Levantine merchants, who were effective in Ottoman trade life, one Hanson family, of English origin, attracted attention with their commercial relations and economic activities. Accordingly, Simpson Hanson (1803-1874) who came to Istanbul for the first time in 1825 and settled for the purpose of commerce, along with his son Henry James Hanson (1838-1935), who was born in Istanbul, together engaged in several commercial fields namely finance, railway construction, import and export. Due to their wide range of business interests, the Hanson Family and their company became prominent among all the Levantine merchants that played a key role in 19th century Ottoman trade. This paper examines different business practices within which Levantine merchants were involved in order to understand how they used Ottoman economic institutions as businessmen between the years 1839 and 1880. This study aims to answer broad questions about the Hanson Family’s role in Ottoman domestic and foreign trade by using primary sources in the Ottoman Archive, the English National Archive and Oxford University Saint Anthony’s College Middle East Center Archive. It will additionally draw from English and Turkish publications belonging to the a forementioned period. These business manners which were applied by the Hanson Company sheds light upon the activities of Levantine Merchants in the Ottoman Empire and their connections with statesmen through business partnerships after the Tanzimat era.