The world population is steadily growing with the continuous push coming from the underdeveloped and developing nations. The more disturbing images of poverty and famine in several parts of our planet seem to occupy the media reports and academic works in the coming decades, due to many new developments. Speeding climate change, the Covid-19, the War in Ukraine and finally the natural disasters which are destroying lands and infrastructures, interrupting farming and industrial facilities, urban and rural life and order. Meanwhile, soaring oil and energy prices are an additional obstacle for the developing countries in overcoming their social and economic problems. Given the unaffordable crude oil and gas prices in the recent past and possibly in the coming years, many countries have no option but re-considering their water resources for regional development, energy and food. In the past 40 years, the situation in the Middle East and in the world has indicated that the dams and irrigation projects had not been the fashion of the 1970s and the 1980s only. Since then, the more countries have applied to freshwater resources in order to increase their energy and food production, including the countries in the Middle East. However, the four successive events which have been taking place one after another, from the climate change and the Covid-19 pandemic to the War in Ukraine and the recent massive earthquakes in the Southern Türkiye, have formed many challenges, setbacks and perhaps opportunities. My paper will assess the challenges, setbacks and may be opportunities in the transboundary river development projetcs and dam management after the massive earthquakes which have occurred in Türkiye, early February. A particular attention will be given to regional development, energy and food security for Türkiye and the adjacent Middle Eastern countries amid the damage left by the quakes. The paper will focus more on the security of the dams, infrastructure, population, energy, irrigation facilities and production. The damage caused by the earthquakes on the cities, rural areas, infrastructure, the quakes-related migration, the loss of work force, businesses and financial sources and their likely impact on the South-East Anatolia(GAP) Project will be analyzed. The paper will apply the concepts and theoretical framework on national security in the context of the development and international political economy.