Bayezid II (1481-1512) might rightly be called as a son of Amasya, the North Central Anatolian city where he spent all his childhood, adolescence and early adulthood as its prince-governor between 1454 and 1481. After his move to Istanbul, Bayezid II cherished Amasya by personally undertaking and encouraging his court members to patronize major construction projects in the city. He also sent his heir apparent, Prince Ahmed (d.1514) as the governor of the city. During his years away from Amasya, Bayezid II surrounded himself with natives of city and the larger Rum region where it is located. His reign witnessed the ascendance of socio-religious, academic, political and artistic networks that originated around his princely court in Amasya and significantly contributed to the formation of Ottoman artistic, scholarly and religious idiom in the subsequent decades. This paper will focus on a significant member of the Amasyan network in Istanbul, the Müeyyedzade brothers. Müeyyedzade Abdürrahman (d.1516), a member of the Ottoman learned hierarchy, not only had a distinguished legal career but also became an important patron of poetry. His brother, Müeyyedzade Abdürrahim on the other hand became the head of a Sufi lodge that was frequented by the Sultan himself. A close examination the family origins, careers and the networks of the Müeyyedzade brothers will reveal how a non-political network flourished in Anatolia was transplanted to and grew within the nascent Ottoman imperial urban platform, i.e. Istanbul. In doing so, it aims to contribute to the study of often ignored non-political networks of Ottoman Istanbul during its formative years in the fifteenth century.